Angaston proved last season that it can be a thorn in the side of most teams without putting them away, finishing with just five wins.
Coach Paul Sherwood said the off-season had benefited the Panthers.
"We've brought in a few new players, to complement our list,” he said.
“We've tried to address a couple of weaknesses in the structure.
“I think general improvement has shown, we’ve got a fair few young guys so we should see improvement.”
Round one will see a difficult task for last year’s seventh placed side, taking on Nuriootpa on Anzac Day.
"It's going to be a tough game, round one's always tough, high expectations, everyone's up," he said.
Angaston has been a steady improving side in the Barossa, Light and Gawler Netball Association over the past few seasons.
Last season they proved they could match it with the best sides, but were unable to cement a finals berth.
The Panthers should be damaging again in 2017, and push the expected top three of Barossa District, Kapunda and South Gawler.